陈飞-HPV自采样进入宫颈癌筛查指南的解析.pdf

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1、2 20 02 26 6 第第六六届届慢慢病病筛筛查查与与管管理理学学术术会会议议HPV自自采采样样进进入入宫宫颈颈癌癌筛筛查查指指南南的的解解析析北北京京协协和和医医院院 陈陈飞飞第六届慢病筛查与管理学术会议第六届慢病筛查与管理学术会议第六届慢病筛查与管理学术会议ONT ENTS目目 录录01HPV自自采采样样进进入入权权威威筛筛查查指指南南02概概念念和和流流程程03可可行行性性解解析析04筛筛查查效效果果研研究究05全全球球应应用用及及规规范范第六届慢病筛查与管理学术会议第六届慢病筛查与管理学术会议第六届慢病筛查与管理学术会议01HPV自自采采样样进进入入权权威威筛筛查查指指南南权权威威

2、指指南南 竞竞相相发发布布第六届慢病筛查与管理学术会议第六届慢病筛查与管理学术会议第六届慢病筛查与管理学术会议01自自采采样样HPV检检测测提提供供了了一一种种新新的的筛筛查查方方式式，使使卫卫生生医医疗疗机机构构能能够够克克服服社社会会文文化化、经经济济、及及交交通通等等障障碍碍开开展展宫宫颈颈癌癌筛筛查查。对对自自采采样样的的推推荐荐：WHO宫宫颈颈癌癌前前病病变变筛筛查查和和治治疗疗指指南南第第二二版版（2021年年）ANNEX 6.ADDITIONAL INFORMATION FOR SCREENING AND TREATMENT RECOMMENDATIONS02向向妇妇女女提提供供

3、自自采采样样检检测测将将有有助助于于其其接接受受并并更更易易获获得得筛筛查查，提提高高筛筛查查覆覆盖盖率率。03自自采采样样需需遵遵循循专专业业指指导导、首首选选经经临临床床验验证证的的基基于于PCR技技术术的的高高危危 HPV DNA检检测测。However,self-collected samples for HPV testing provide an additional strategy to overcome cultural and logistical barriers towards accessing the health system and the reference

4、laboratory or hospital screening programme.Acceptability,equity,feasibility,resources(all recommendations):A systematic review of the literature,primarily in high-income countries,found that HPV DNA testing by self-sampling is likelyto improve screening uptake and may improve follow-up care slightly

5、(Web annex A,Supplementary material 12).4.1.2 Summary of the evidence Although it was not modelled,the sensitivity and specificity of self-collected upper vaginal samples for HPV testing may be similar to those of cervical samples taken by health-care providers for the detection of CIN2+using clinic

6、ally validated polymerase chain reaction(PCR)-based high-risk HPV DNA tests.World Health Organization.WHO guideline for screeningand treatment of cervical precancer lesions for cervicalcancer prevention,second edition.2021R/OL.(20210706)20220808.https:/www.who.int/publications/i/item/9789240030824.第