小鼠基因驱动.pdf

1、United States Department of AgricultureAnimal and Plant Health Inspection ServiceWildlife Services National Wildlife Research CenterStatus of gene drive in miceAntoinette J.Piaggio,Ph.D.USDA WS National Wildlife Research CenterUSDA/WS-NWRC MissionUS Department of Agriculture/Animal Plant Health Insp

2、ection Service/Wildlife Services has an operational branch and a research branch(NWRC)Mission:is to apply scientific expertise to resolve human-wildlife conflicts while maintaining the quality of the environment shared with wildlife.NWRC develops methods and information to address human-wildlife con

3、flicts related to the following:AgricultureWildlife diseaseHuman health and safetyProperty damageInvasive speciesOne Health frameworkOne Health InitiativeProblemUS Ag$19b/yrhttp:/diise.islandconservation.org/Invasive alien mammal eradications-2016 1100 successful Result in native species recoveryDat

4、abase of Island Database of Island Invasive Species Invasive Species EradicationsEradicationsToxicants Moderate failure rate Challenging to use in inhabited areas Off-target effects and animal welfare concernsHow is control done today and what are the limitations?United States Department of Agricult

5、ureAnimal and Plant Health Inspection ServiceWildlife Services National Wildlife Research CenterUS REGULATORYREPRODUCTIVECOMPETITIONRISK ASSESSMENTAU REGULATORYSTAKEHOLDERENGAGEMENTCRISPRCas9 MICEISLAND MICEGENETICSISLANDSELECTIONCOMMs,MEDIA,TRANSPARENCYNZ REGULATORYMODELINGIPBIOSAFETY/CONTAINMENT/L

6、OCALIZATIONSUSTAINABILITY/FUNDRAISINGETHICS ADVISORY COMMITTEEGenetic Biocontrol of Invasive RodentsGBIRd PRGRMMGMTt-Sry MICERODENTECOLOGY2015DARPA Safe Genes 2017Biosecure Facilities2ocontainment is ribbon of sticky traps&live traps1ocontainment is 16 x 16 mo