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福泰制药Vertex Pharmaceuticals(VRTX)2024年10-K年度报告「NASDAQ」(英文版)(202页).pdf

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1、UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWASHINGTON,D.C.20549FORM 10-K ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d)OF THE SECURITIES EXCHANGE ACT OF 1934For the Fiscal Year Ended December 31,2024or TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)OF THE SECURITIES EXCHANGE ACT OF 1934FOR THE

2、TRANSITION PERIOD FROM TO Commission file number 000-19319Vertex Pharmaceuticals Incorporated(Exact name of registrant as specified in its charter)Massachusetts(State or other jurisdiction of incorporation or organization)50 Northern Avenue,Boston,Massachusetts(Address of principal executive offices

3、)04-3039129(I.R.S.Employer Identification No.)02210(Zip Code)Registrants telephone number,including area code(617)341-6100Securities registered pursuant to Section 12(b)of the Exchange Act:Title of Each ClassTrading SymbolName of Each Exchange on Which RegisteredCommon Stock,$0.01 Par Value Per Shar

4、eVRTXThe Nasdaq Global Select MarketSecurities registered pursuant to Section 12(g)of the Exchange Act:NoneIndicate by check mark if the registrant is a well-known seasoned issuer,as defined in Rule 405 of the Securities Act.Yes No Indicate by check mark if the registrant is not required to file rep

5、orts pursuant to Section 13 or Section 15(d)of the Exchange Act.Yes No Indicate by check mark whether the registrant:(1)has filed all reports required to be filed by Section 13 or 15(d)of the Securities Exchange Act of 1934 during the preceding 12 months(or forsuch shorter period that the registrant

6、 was required to file such reports),and(2)has been subject to such filing requirements for the past 90 days.Yes No Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T(232.405 of this ch

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本文主要介绍了Vertex Pharmaceuticals Incorporated(Vertex制药公司)的业务概况。Vertex是一家全球生物技术公司,专注于为患有严重疾病的患者开发创新药物,重点关注专科市场。 Vertex目前有七种已批准的药物,包括五种用于治疗囊性纤维化(CF)的药物,一种用于治疗严重镰状细胞病(SCD)和输血依赖性β地中海贫血(TDT)的药物,以及一种用于治疗中度至重度急性疼痛的药物。 Vertex的CF药物包括TRIKAFTA/KAFTRIO、SYMDEKO/SYMKEVI、ORKAMBI和KALYDECO,这些药物正在美国、欧洲、澳大利亚和加拿大等地区为近四分之三的CF患者提供治疗。2024年12月,FDA批准了Vertex的第五种CF药物ALYFTREK,用于治疗6岁及以上CF患者。 Vertex的SCD和TDT药物CASGEVY已在美国、欧盟、英国、沙特阿拉伯、巴林、阿联酋、加拿大和瑞士获得批准。Vertex估计,在美国、加拿大、欧洲、沙特阿拉伯和巴林,约有60,000名严重SCD或TDT患者有资格接受CASGEVY治疗。 2025年1月,FDA批准了Vertex的急性疼痛药物JOURNAVX,用于成人中度至重度急性疼痛的治疗。 Vertex还在多个疾病领域和治疗方式上进行研究,包括APOL1介导的肾脏疾病、IgA肾病、1型糖尿病、肌强直性营养不良1型和常染色体显性多囊肾病等。
什么是囊性纤维化? 什么是镰状细胞病和输血依赖性β地中海贫血? 什么是急性疼痛?
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