多层连续流微流体生物芯片的动态拓扑感知流路构建与调度优化.pdf

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1、Dynamic Topology-Aware Flow PathConstruction and Scheduling Optimizationfor Multilayered Continuous-FlowMicrofluidic BiochipsMeng Lian,Shucheng Yang,Mengchu Li,Tsun-Ming Tseng,and Ulf SchlichtmannTechnical University of Munich,Munich,GermanyOutline1.Multilayered Continuous-Flow Microfluidic Biochips

2、2.Challenges Conflict Dynamic Topological Change3.Our Method Problem Formulation Quadratic Programming Model4.Experimental Results21.Multilayered Continuous-Flow Microfluidic Biochips3Fig.1:Schematic of a multilayered continuous-flow microfluidic biochips.2.Challenges Conflict Parallel-executed oper

3、ations Contaminated reaction products Unexpected channel blockages Limitations of existing methods Identification1:fluids traverse common components.Resolution:sequential execution4source:1 Wajid Hassan Minhass,Paul Pop,and Jan Madsen.System-level modeling and synthesis of flow-based microfluidic bi

4、ochips,CASES,2011.2 Tsun-Ming Tseng et al.Columba 2.0:A co-layout synthesis tool for continuous-flow microfluidic biochips,IEEE TCAD,2018.Fig.2:A partial biochip synthesized using Columba 2.02.2.Challenges Dynamic Topological Change Hydraulic behavior Hagen-Poiseuilles law3 Ohms law Recall Equivalen

5、t fluid circuit:5source:3 Kwang W.Oh,Kangsun Lee,Byungwook Ahn,and Edward P.Furlani.Design of pressure-driven microfluidic networks using electric circuit analogy,Lab Chip,2012.(a)(b)2.Challenges Dynamic Topological Change Constant flow velocity1,4 Non-serial connection Parallel connection:Bridge co

6、nnection:6source:1 Wajid Hassan Minhass,Paul Pop,and Jan Madsen.System-level modeling and synthesis of flow-based microfluidic biochips,CASES,2011.4 Wajid Hassan Minhass et al.Scheduling and fluid routing for flow-based microfluidic laboratories-on-a-chip,IEEE TCAD,2018.(a)(b)2.Challenges Dynamic To