疫情调查剖析.pdf

1、The Anatomy of an Outbreak InvestigationPresented by:Drew McDonald,Taylor FarmsCharles Leftwich,SYSCONick Waters,SYSCOMelanie Neumann,Neumann Advisory Services,LLCThe Skeleton Outline for Today What is an Outbreak?Surveillance and outbreak detection:how companies become implicated as a possible outb

2、reak source What happens if CDC and FDA call a company to implicate them as source of an outbreak.Other reasons why CDC or FDA may contact you about food safety issues(potentially)linked to your facility War stories;legal implications How to prepare for the“worst-case scenario”Africa 91M cases 137,0

3、00 deathsFoodborne Illness Annual Estimates World Health OrganizationWHO Global FBD estimates 600 million cases 420,000 deathsRegion of the Americas 77M cases 9,000 deathsEuropean Region 23M cases 4654 deathsEastern Mediterranean 100M cases 37,000 deathsSouth-East Asia 150M cases 175,000 deathsWeste

4、rn Pacific 125M cases 50,000 deathsWhat is an Outbreak?According to the CDC,a foodborne illness outbreak is defined as when two or more people experience a similar illness after consuming the same contaminated food or drink.Outbreak Surveillance and Detection Cluster(Traditional)and Sample-Initiated

5、 Outbreak Investigation ModelsCluster-initiated Sample-InitiatedTWO MAIN DETECTION&INVESTIGATION PATHWAYSCluster-Initiated Outbreak InvestigationTwo or more humans:Test positive for a foodborne pathogen(e.g.,Salmonella)The bacteria isolated from these people are found to be“identical,”a“match”or“clo

6、sely related/associated”by whole genome sequencing(WGS)SNPS:the common measures What is a SNP?Single Nucleotide Polymorphism A SNP is a variation in the DNA sequence where a single nucleotide(A,T,C,or G)is different between individuals or strains.In food WGS,SNPs are used to compare the genomes of d