粉末的安全处理并遵守容器要求.pdf

1、SAFE HANDLING OF POWDERSWITH CONTAINMENT REQUIREMENTS21/May/2025 Pharma Summit IrelandMartin Rohse.Martin Rohse37 years experience in powder handling.Working in different positions for manufacturers and process equipment suppliers.Focus is always on,PHARMA-CHEMICAL-and FOOD-applications.23 Head quar

2、ter in Pfaffenhofen,50 km north of Munich,Sister companies in the USA and BeNeLux More than 140 employees Approx.1000 customers Pharma,Food und Chemical industries Delivered units to 50 countries About usAs your,reliable partner in the safe handling of bulk materials,our family-owned company stands

3、for tailor made and efficient solutions.4For each product line,we offer various standard solutions or adapt them to the customers individual requirements.5Our range of productsCONTAINMENT BASICS7DefinitionProduct and personal protectionthrough the use of closed systems.Protection of the operator aga

4、instsubstances hazardous to health(toxic,mutagenic,carcinogenic).Protection of the product from cross-contaminationand impurities.Containment BasicsClassification Containment Basics8Product examples 9Containment Basics OEB 1:low risk Handling of L-Ascorbic acid OEB 2:moderate risk Handling of Acetyl

5、salic acid OEB 3:moderate up to high risk Nickel Magan Cobalt(NMC)OEB 4:high risk handling of Cisplatin OEB 5:extreme high risk Handling of Botulinumtoxin(Botox)Empire State Buildingca.400 m high,7000 m2 base Volume:ca.1.050.000 m Sugar stick:ca.4 g(4.000.000 g)Corresponding Concentration:3,81 g/m O

6、EL 1-10g/m(OEB 4)10ExampleContainment BasicsPrimary Containment Secondary Containment11Containment Basics12Influencing variables Bulk solids:density,particle size distribution,flowability,explosion protection,OEL values(toxicity)Process:pressure,temperature,filter concept,interfa