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Syndax_JPM 2025_FINAL_.pdf

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1、Syndax Corporate Presentation43rdAnnual J.P.Morgan Healthcare ConferenceJanuary 14,2025Forward-looking statements disclosureThis presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.Words such asmay,will,expect,plan,anticipate an

2、d similar expressions(as well as other words or expressions referencing future events,progress,timing or circumstances)are intended to identify forward-looking statements.All statements other than statements of historical facts containedin this presentation,including statements regarding future oper

3、ations,financial results and the financial condition of Syndax Pharmaceuticals,Inc.(“Syndax”or the“Company”),including financial position,strategy and plans,the progress,timing,clinical development and scope ofclinical trials and the reporting of clinical data for Syndaxs product candidates,the prog

4、ress of regulatory submissions and approvals andsubsequent commercialization and the potential use of Syndaxs product candidates to treat various cancer indications and fibrotic diseases,andSyndaxs expectations for liquidity and future operations,are forward-looking statements.Many factors may cause

5、 differences between currentexpectations and actual results,including unexpected safety or efficacy data observed during preclinical studies or clinical trials,clinical siteactivation rates or clinical trial enrollment rates that are lower than expected;changes in expected or existing competition;th

6、e impact ofmacroeconomic conditions(the Russia-Ukraine war,inflation,among others)on Syndaxs business and that of the third parties on which Syndaxdepends,including delaying or otherwise disrupting Syndaxs clinical trials and preclinical studies,manufacturing and supply chain,or impairingemployee pr

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根据报告的内容,本文主要介绍了Syndax公司2025年J.P. Morgan医疗保健会议的企业演示文稿。主要内容包括: 1. Syndax是一家商业阶段的肿瘤公司,拥有两种具有实践改变性和数十亿美元潜力的首创新药。 2. Syndax在2024年实现了多个重大里程碑,包括两次FDA批准,在约90天内连续获得批准。 3. Syndax的Revuforj(revumenib)是首个也是唯一获批的menin抑制剂,用于治疗成人及1岁及以上儿童中具有KMT2A重排的复发或难治性急性白血病。 4. Syndax正在积极执行其menin策略,以推动长期增长,包括扩大Revuforj在R/R mNPM1 AML中的批准范围,将其推进到一线治疗,并确保首创新药优势。 5. Syndax的Niktimvo(axatilimab-csfr)是一种CSF-1R抑制剂,用于治疗慢性移植物抗宿主病(cGVHD),具有潜在的市场扩展潜力。 6. Syndax预计在2025年实现盈利,拥有7.5亿美元的现金储备,预计将支持公司实现盈利。 7. Syndax致力于实现一个未来,即癌症患者能够比以往任何时候都活得更长、更好。
什么是Menin抑制剂,它如何改变急性白血病的治疗? Syndax的Revuforj如何成为治疗复发或难治性急性白血病的首选药物? Syndax的Niktimvo如何通过抑制CSF-1R来治疗慢性移植物抗宿主病?
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