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Arbutus Corporate Presentation_Jan 13 2025_FINAL-v3.pdf

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1、NASDAQ:ABUS January 13,2025Corporate Presentation 2025 Arbutus Biopharma,Inc.Forward-Looking StatementsThis presentation contains forward-looking statements within the meaning of the U.S.Private Securities Litigation Reform Act of 1995 and Canadian securities laws.All statements that are not histori

2、cal facts are hereby identified as forward-looking statements for this purpose and include,among others,statements relating to:the potential market opportunity for HBV;Arbutus ability to meet a significant unmet medical need;the sufficiency of Arbutus cash and cash equivalents for the anticipated du

3、rations;the expected cost,timing and results of Arbutus clinical development plans and clinical trials,including its clinical collaborations with third parties;the potential for Arbutus product candidates to achieve their desired or anticipated outcomes;Arbutus expectations regarding the timing and

4、clinical development of Arbutus product candidates,including its articulated clinical objectives;the timeline to a combination cure for HBV;Arbutus expectations regarding its technology licensed to third parties;the expected timing and payments associated with strategic and/or licensing agreements;A

5、rbutus expectations with respect to utilizing its ATM program;the patent infringement lawsuits;and other statements relating to Arbutus future operations,future financial performance,future financial condition,prospects or other future events.With respect to the forward-looking statements contained

6、in this presentation,Arbutus has made numerous assumptions regarding,among other things:the timely receipt of expected payments;the effectiveness and timeliness of clinical trials,and the usefulness of the data;the timeliness of regulatory approvals;the continued demand for Arbutus assets;and the st

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根据标记中的内容,本文主要介绍了Arbutus Biopharma公司(ABUS)的概况和其针对慢性乙型肝炎(HBV)的药物研发进展。主要内容包括: 1. Arbutus专注于开发慢性HBV的功能性治愈方案,目前主要药物是RNAi治疗药物imdusiran,正在进入第2b阶段的临床试验。 2. imdusiran在临床试验中显示出良好的安全性和耐受性,与短期干扰素联合使用时,50%的患者实现了功能性治愈。 3. Arbutus还开发了口服PD-L1抑制剂AB-101,用于HBV免疫再激活,目前正在进行第1a/1b阶段的临床试验。 4. 公司拥有强大的财务状况,截至2024年底,现金余额为1.23亿美元,预计现金使用期可至2028年第一季度。 5. Arbutus正在与Qilu Pharmaceutical合作开发和商业化imdusiran在大中华区,并正在寻求对Moderna和Pfizer/BioNTech的COVID-19疫苗销售提起的专利侵权诉讼的赔偿。
Arbutus的HBV治疗药物imdusiran在临床试验中表现如何? Arbutus与Qilu的合作对imdusiran的商业化有何影响? Arbutus的专利诉讼案进展如何,对公司有何影响?
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