1、 FUNGAL INFECTIONS:NEW CHALLENGES IN TREATMENT CAS INSIGHTS REPORT EXECUTIVE SUMMARY Fungal infections represent a significant and growing threat to global health,affecting millions of individuals annually.These infections range from superficial conditions,such as athletes foot and oral thrush,to se

2、vere,life-threatening systemic diseases like invasive candidiasis,aspergillosis,and cryptococcosis.Several factors are fueling an increase in fungal disease incidence and complications with treatment.Climate change and healthcare-associated infections are changing emergence patterns,increasing the o

3、pportunity for fungal infections.The cost of new drug development is also slowing down the process of finding new clinical treatments for these infections.While research would normally increase at this stage,were seeing publications and clinical trials level off and decline.Fortunately,many innovati

4、ve approaches are available to improve fungal disease treatment.AI and genetic editing are important new treatment options.Drug repurposing and combination therapies are leveraging existing medications for better effectiveness.Biomaterials and improved delivery methods are also providing potential n

5、ew approaches.With renewed interest from researchers and the pharmaceutical industry,we can implement breakthroughs in treating fungal infections and stave off worsening conditions in the incidence of these infections for patients worldwide.Table of Contents Introduction:The growing problem of funga

6、l diseases.2 Major classes of antifungals.3 Mechanisms of antifungal resistance.5 Research trends in antifungals reveal the need to identify new treatments.7 Clinical trials slowing down.12 Researchers exploring more treatment approaches for new antifungals.15 Identifying newer fungal targets.15 Imp