1、 NEW TECHNIQUES IN ASSISTED REPRODUCTIVE TECHNOLOGY CAS INSIGHTS REPORT EXECUTIVE SUMMARY Assisted reproductive technologies(ART)have revolutionized reproductive medicine,offering hope to millions facing fertility problems through methods like artificial insemination to cutting-edge gene editing.Whi

2、le established techniques such as in vitro fertilization and intracytoplasmic sperm injection are widely used today,emerging technologies such as in vitro gametogenesis,gene therapies,and stem cell-based therapies are expanding the boundaries of what is possible.ART is a rapidly advancing field,but

3、the use of certain novel and emerging technologies in humans is still highly experimental,tightly regulated,and surrounded by ethical and legal challenges.Many innovations in ART are being tested only on animal models,yet some have successfully transitioned to human applications,including preimplant

4、ation genetic testing,mitochondrial replacement therapy,time-lapse imaging,and in vitro maturation.Furthermore,artificial intelligence is transforming reproductive medicine by enabling precise embryo selection,optimizing clinical protocols,and predicting treatment outcomes.This report explores data

5、from the CAS Content Collection to outline the research progress in ART and identify key emerging concepts and challenges to better understand how ART is shaping the future of reproductive healthcare.Table of Contents State of the ART:An introduction.2 Current methods of assisted reproductive techno

6、logy.3 Fastest-growing ART methods:AI and in vitro gametogenesis.5 AI in ART.5 IVG in ART.6 Methods of greatest commercial interest:Stem-cell therapies and gene editing.7 Stem cell-based therapies.7 Gene editing.8 Additional novel methods in ART.9 Genetic screening.9 Mitochondrial replacement therap