1、 United States Government Accountability Office Report to Congressional Addressees TECHNOLOGY ASSESSMENT Human Organ-on-a-Chip Technologies Offer Benefits Over Animal Testing but Challenges Limit Wider Adoption May 2025 GAO-25-107335 The cover image displays a stylized representation of an organ-on-

2、a-chip.Cover source:GAO analysis of scientific literature(data and illustration);Paul/Bidala/Kwangmoozaa/Kuz Production/Pakhnyushchyy/(images).|GAO-25-107335 United States Government Accountability Office Highlights of GAO-25-107335,a report to congressional addressees May 2025 TECHNOLOGY ASSESSMENT

3、 Human Organ-on-a-Chip Technologies Offer Benefits Over Animal Testing but Challenges Limit Wider Adoption What GAO found Human organ-on-a-chip(OOC)is an emerging technology that incorporates human adult cells in a small laboratory device to mimic how organs worksuch as the brain,heart,or lungs.OOCs

4、 may be designed to simulate the mechanics of human organs,such as a lung-on-a-chip that stretches to simulate breathing.Researchers are developing and using OOCs to model diseases and predict responses to chemicals.For example,companies are using OOCs to assess aspects of drug safety and efficacy.B

5、ecause OOCs contain human cells,their use in research may have more relevance to humans than animal testing or other conventional lab methods,but certain OOC research may cost more and take longer.Currently,OOCs cannot replace animal testing but may be used alongside animals.The next generation of O

6、OC is focused on developing“body-on-a-chip”systems that link together multiple OOCssuch as the intestine,liver,and kidneyto investigate how organs interact.Lung-on-a-chip(left)and how organ-on-a-chip compares to animals(right)GAO identified several challenges to the development and use of OOCs,inclu