1、2025 Vertex Pharmaceuticals Incorporated 2025 Vertex Pharmaceuticals Incorporated FIRST QUARTER 2025 FINANCIAL RESULTS2025 Vertex Pharmaceuticals IncorporatedFirst Quarter 2025Financial ResultsMay 5,20252025 Vertex Pharmaceuticals Incorporated 2AgendaIntroduction Susie Lisa,CFA,Senior Vice President

2、,Investor RelationsCEO Perspective and Pipeline Update Reshma Kewalramani,M.D.,Chief Executive Officer and PresidentCommercial Update Stuart Arbuckle,Executive Vice President and Chief Operating Officer Duncan McKechnie,SVP,North America Commercial Operations Chief Commercial Officer(as of July 1,20

3、25)Financial Results Charlie Wagner,Executive Vice President and Chief Financial Officer2025 Vertex Pharmaceuticals Incorporated 3Safe harbor statement&non-GAAP financial measuresThis presentation contains forward-looking statements that are subject to risks,uncertainties and other factors.All state

4、ments other than statements of historical fact are statements that could be deemed forward-looking statements,including all statements regarding the intent,belief,or current expectation of Vertex and members of the Vertex senior management team.Forward-looking statements are not purely historical an

5、d may be accompanied by words such as“anticipates,”“may,”“forecasts,”“expects,”“intends,”“plans,”“potentially,”“believes,”“seeks,”“estimates,”and other words and terms of similar meaning.Such statements include,without limitation,the information provided regarding and expectations for future financi

6、al and operating performance,the section captioned“Updated full year 2025 financial guidance,”expectations for financial performance in Q1 2025,and statements regarding(i)expectations,development plans and timelines for Vertexs products and pipeline programs,including beliefs regarding the status of