1、Annual Report 2024This picture shows special nerve cells,so-called motor neurons,which are derived from human stem cells.The neurons are guided through tiny,maze-like channels,which helps researchers to understand their growth and connections and to learn about nerve diseases and treatments.Photo:Ja

2、mes Keaney,pRED scientistWe drive innovationIt starts with an idea nurtured by the belief that we can always do better.Propelled by curious minds pursuing scientific excellence and pushing the boundaries of what is possible.An evolution centred around a single anchor innovation.In all our innovation

3、 engines around the world,we foster an environment where our researchers endeavour to shape the future ofhealthcare.In 2024,we proudly opened a new R&D facility in Switzerland.The Roche Innovation Center Basel is equipped with state-of-the-art labs and technology to foster creativity and collaborati

4、on in tackling healthcares biggest challenges and to advance science,so we all have more time with the people we love.Annual Report 2024|Roche 1Immune cells seen in gastrointestinal cancer tissuetheir presence in many solid tumours suggestsan ongoing immune reaction and,therefore,the manipulation of

5、 them for therapeutic purposes represents an exciting future avenue of research.Photo:Miguel Camacho,Marius Harter,IrinejaCubela,pRED scientistsContentsLetters to shareholders 5 Sustainability Report 15 How we contribute 151Corporate Governance 163 Remuneration Report Report 2024|Roche 3These cells

6、are macrophages derived from induced pluripotent stem cells,stained for varioussubcellular structures and used in complexfunctional cellular assays to examine processes such as phagocytosis,migration andcytokine release.Photo:Ramona Schfer,Nadine Dahm,SimonGutbier,pRED scientistsLetters to sharehold