元奕咨询：2024年类器官和器官芯片行业发展现状分析和趋势创想报告（66页）.pdf

1、2024.9基础概念文章发表和专利申请激增DPI统计了类器官72项注册临床试验，肿瘤学是最主要的试验方向T.Sato,H.Clevers et al.(2015)Cell.2019Kim M,et al.Patient-derived lung cancer organoids asin vitro cancer models for therapeutic screening.Nat Commun.2019;10:3991.2020Shi R,et al.Organoid cultures as preclinicalmodels of non-small cell lung cancer.

2、Clin Cancer Res.2020;26:116274.2021Dekkers JF,et al.Long-term culture,geneticmanipulation and xenotransplantation of human normal and breast cancerorganoids.Nat Protoc.2021;16:193665.2018Yan HHN,et al.A comprehensive human gastric cancerorganoid biobank captures tumor subtype heterogeneity and enabl

3、es therapeuticscreening.Cell Stem Cell.2018;23(88297):e11.2018Nuciforo S,et al.Organoid models of human liver cancers derived from tumor needle biopsies.Cell Rep.2018;24:136376.2019Yan Z,et al.Inhibition of ERK1/2 incancer-associated pancreatic stellate cells suppresses cancer-stromalinteraction and

4、 metastasis.J Exp Clin Cancer Res.2019;38:221.2020Yao Y,et al.Patient-derived organoids predict chemoradiation responses of locally advanced rectal cancer.Cell Stem Cell.2020;26(1726):e6.2020Esser LK,et al.Cultivation of clear cellrenal cell carcinoma patient-derived organoids in an air-liquid inter

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6、cancer.Cancer Res.2021;81(24):620718.类器官在癌症治疗领域发展类器官在癌症治疗领域发展器官芯片可以从以下几个方面促进细胞球和类器官的建立：时空信号调控 力学刺激及检测 高通量分析 共培养和互作体系构建 生物传感成像集成器官芯片定义器官芯片定义作用原理：器官芯片由两个平行的微流控通道（1、6）组成，其中一个通道用于上皮细胞（2），另一个通道用于内皮细胞（5）。多孔膜（4）分隔了两个通道，同时实现了通道间的交流和细胞迁移。微流控通道旁边的真空通道（3）提供了对膜的可调机械拉伸。拉伸示意图hESCs/HUVECs C.parvum oocysts3D:96T PD