控制肉鸡新出现的健康问题——包涵体肝炎的策略.pdf

1、Strategies to control Inclusion Body Hepatitis(IBH)an emerging health problem in broilers M.R.ReddyICAR-Directorate of Poultry ResearchHyderabad-500030,TG,IndiaOutlineInclusion body hepatitis(IBH)is an acute disease of young broiler chickens caused by several serotypes of fowl adenovirus(FAdV),chara

2、cterized by intranuclear inclusion bodies in hepatic cells.FAdV serotypes Clinical disease Risk Factors Diagnosis of IBH Outbreak Handling Prevention strategies Monitoring Disease/vaccinnationFowl Adenovirus-SerotypesAviadenovirus(Gr-I)Fowl AdenovirusGoose AdenovirusDuck AdenovirusTurkey AdenovirusP

3、igeon AdenovirusAdenoviridae FAdV-AFAdV-CFAdV-DFAdV-BFAdV-E154,102,3,9,116,7,8a,8bAtadenovirus(Gr-III)Chicken:EDS VirusSiadenovirus(Gr-II)Turkey:HEVPheasant:MSDVChicken:AASVIBHHHPSSPECIESSEROTYPEGEUUnique Features of FAdV A medium sized(75-90nm),Naked(Non-enveloped)virus Virus appears like a space v

4、ehicle dsDNA Genome(43kb)Withstand pH range of 3 to 9 Resistant to sunlight&Heat 70C/30min Resistant to common disinfectants Can remain infective in the environment for long periods Replicate in nucleus and release by cell lysis-death Mixed infection recombinationA tough outer protein coat(capsid)is

5、 more resistant to degradationCore genetic material,made of double-stranded DNA,is more stable Prevalence of FAdV Serotypes Circulating in India Earlier outbreaks:Mainly due to FAdV-4 Recent outbreaks:FAdV-8b and FAdV-11 The decline of FAdV-4 may be due to application of FAdV-4 vaccine Emergence of

6、FAdV-8b&FAdV-11 indicate no cross protection by FAdV-4 vaccinesFAdV-1178.2%FAdV-8b16.9%FAdV-8a0.8%FAdV-20.8%FAdV-43.2%Epidemiology FAdVs are widespread in chickens Birds can be infected with more than one serotype Broilers are more susceptible with higher mortality due to:Severe metabolic imbalance