仿生数字孪生和多组学：在类风湿性关节炎中的应用以了解疾病的分子机制.pptx

1、Biomimetic Digital Twins and Multiomics:Applications to Rheumatoid Arthritis to Understand the Molecular Mechanisms of Disease,William G.Kearns,NYSDS09-17-2024,NAS-2022 Opportunities and Challenges for Digital Twins in Biomedical Research.DOI:https:/doi.org/10.17226/26922,NAS published a 164-page re

2、port:“Foundational Research Gaps and Future Directions for Digital Twins”(December 15,2023),National Academies of Sciences,Engineering,and Medicine.2023.Foundational Research Gaps and Future Directions for Digital Twins.Washington,DC:The National Academies Press.https:/doi.org/10.17226/26894,Digital

3、 Twin(DT)Technologies,Biomimetic DT Ecosystems,Model agents or independent components of a problem domain that may interactOutput real-world evidence of previously unseen interactionsBiomimetic design supports interactions between models of diverse domains and scales enabling discovery&learning,Mech

4、anistic DT Methods,Model defined systems or subsystemsSimulate or predict the behavior of the model in diverse scenariosMechanistic design limits the learning from interactions between models of diverse domains and scales,Technical Advance Using Multiomics and Biomimetic Digital Twins-Endometriosis,

5、Kearns WG,Stamoulis G,Glick J,Baisch L,Benner A,Brough D,Du L,Wilson B,Kearns L,Ng N,Seshan M,Anchan R.The Application of Knowledge Engineering via the Use of a Biomimetic Digital Twin Ecosystem,Phenotype-Driven Variant Analysis,and Exome Sequencing to Understand the Molecular Mechanisms of Disease.

6、Key Result The identification of a potential biomarker in Muc20Biomimetic methodology enabled the use of small and diverse dataJ Mol Diagn.2024 Jul;26(7):543-551.doi:10.1016/j.jmoldx.2024.03.004.Epub 2024 Mar 29.PMID:38556123,5,Rheumatoid Arthritis,Published papers identified 6786 gene inter-relatio