1、Emerging Targets:Cancer Therapy(April 2023)Emerging targets in Cancer therapyIntroduction:Cancer is a group of diseases characterized by the abnormal growth and spread of cells in the body that arises due to genetic mutations and environmental factors.It has been a major cause of morbidity and morta

2、lity worldwide,with an estimated 10 million deaths in 2020 alone.Currently,the two major approaches used for cancer treatment include targeted therapy and non-targeted therapy.Non-targeted therapy,also known as conventional chemotherapy,involves the use of cytotoxic drugs that kill both cancerous an

3、d healthy cells.Non-targeted therapy,while less specific in its targeting,can be effective in treating certain types of cancer.It is also generally less expensive than targeted Targeted therapy,on the other hand,uses drugs that specifically target cancer cells while sparing healthy cells.One of the

4、main advantages of targeted therapy is its ability to selectively target cancer cells,resulting in fewer side effects than non-targeted therapy.Targeted therapy can also be more effective at killing cancer cells,as it can exploitspecific genetic or molecular vulnerabilities in cancer cells.Additiona

5、lly,targetedtherapy can sometimes be used in combination with non-targeted therapy,such as chemotherapy,to enhance its effectiveness.Targeted therapy has been an industry standard in specific cancer treatments with the firsttargeted therapy being approved as early as 1970s when tamoxifen was approve

6、d for thetreatment of ER-positive breast cancer.Since then,multiple new targets have beendiscovered for cancer treatment with multiple drugs attaining blockbuster sales.For the identification of potential cancer targets,primary data source utilized for the reportwas the AdisInsight database( drug pr