1、BIOMARKERS INSIGHT REPORT|1BIOMARKERSThe key to early cancer detectionCAS INSIGHTSTMCancer is a leading cause of death worldwide.1 With its incidence expected to rise,2 early detection is critical to reducing morbidity and mortality with higher survival rates,the possibility for less invasive treatm

2、ents with fewer side effects,and less emotional burden on patients and their families.3,4 It can also reduce costs and help fuel research into cancer detection and treatment.Cancer biomarkers provide information about cancer and are,therefore,essential tools for early detection.A biomarker is any bi

3、omolecule,cellular structure,or bioactivity that can be measured and evaluated as an indicator of pathogenic processes,normal biological processes,or pharmacological responses to a treatment.5,6In this report,we examine data from the CAS Content Collection,7 the largest human-curated collection of p

4、ublished scientific information,to provide insights into advances in cancer biomarkers.We look at trends in specific cancers,geographic regions,types of biomarkers,as well as investment and clinical trials.We also explore Excelras Biomarker Insights dataset,which contains manually compiled biomarker

5、 information for selected disease indications.We have put a special emphasis on pancreatic and liver cancers because they are known to be difficult to detect early,with high morbidity and mortality.811IntroductionCopyright CAS,a division of the American Chemical Society and Excelra Knowledge Solutio

6、ns,Pvt.Ltd.All rights reserved.No part of this report may be reproduced or distributed by any means,or stored in a database or retrieval system,without the prior written permission of the copyright ownersBIOMARKERS INSIGHT REPORT|3What makes a biomarker?What are biomarkers?Cancer biomarkers belong t